Our team developed a simplified version of a nucleic acid based detection technology that offers early detection of the virus from 0-5 days of illness. This newly developed procedure, the Loop-Mediated Isothermal Amplification
(LAMP) Assay proposed by Notomi et al., offers several advantages which can augment for the shortcomings of existing nucleic-acid based protocols. The miniaturized version of this LAMP technology called the Biotek-MTM has been
tested in the laboratory and promises to be applicable even in the field and other primary health care settings where only basic laboratory equipment are available. The Biotek-MTM is also able to identify the serotype of the
dengue virus. The initial field testing of this new test showed a sensitivity of 0.851 (95% Confidence Interval CI 0.747-0.917); specificity of 0.76 (95% CI 0.626-0.857); positive predictive value (PPV) 0.826 (95% CI 0.720-0.898);
negative predictive value (NPV) 0.792 (0.657-0.883); positive likelihood ratio (LR+) 3.545 (95% CI 2.143-5.864) and negative likelihood ratio (LR-) 0.196 (0.109-0.355) during its pilot testing done in Metro Manila, Philippines from 2011 to 2010.
BIOTEK-M PORTAL
Technicom (Roll-out)
Clinical Validation.
The UPM - IBBC is organizing a Training Program for Laboratory Biosafety and Biosecurity Officers to commence in the second quarter of 2016. The main objective of the program is to develop a pool of local trainers who will undertake advocacy and continuing education on laboratory biosafety and biosecurity. At the end of the training, the trainers are expected to be competent in the following areas:
*Biosafety and biosecurity risk assessment *Laboratory vivarium Biosafety and Biosecurity *Biocontainment practices and procedures *Biocontainment facilities *Use of safety equipment *Incident response procedures *Infectious substance transport *Biosafety program management *Management of transgenic materials *Regulatory framework of transgenic materials
The training will entail at least ten modules, each of which with duration of two weeks, scheduled on July 18-29, 2016; September 18- October 1, 2016; and November 20- December 3, 2016.
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